Promethazine is metabolized because of the liver to a variety of inactive metabolites for instance sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.
Tell your physician Should you be pregnant or think you may well be Expecting. All through pregnancy, this item is just not encouraged. It may harm an unborn toddler. Check with your doctor about the risks and benefits of this medication. See also Warning area.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients a lot less than six yrs of age, mainly because the combination may possibly lead to lethal respiratory depression Within this age inhabitants (see WARNINGS – Box Warning and Use In Pediatric People).
Steps of histamine on H1receptors increases capillary permeability and edema formation, flare and pruritus.
Continue to keep a list of the many products you employ (together with prescription/nonprescription prescription drugs and herbal products) and share it with your doctor and pharmacist. Tend not to get started, cease, or alter the dosage of any medicines without your health care provider's acceptance.
This medication might cause many people to become dizzy, lightheaded, drowsy, or a lot less warn than These are Generally. Whether or not taken at bedtime, it might result in a number of people to come to feel drowsy or significantly less inform on arising.
Pregnancy Tests: Diagnostic pregnancy exams dependant on immunological reactions among HCG and anti-HCG could bring about Fake-destructive or Untrue-optimistic interpretations.
Promethazine and codeine need to be made use of in the course of pregnancy provided that the prospective benefit justifies the prospective possibility towards the fetus.
The specific mechanism of action of codeine and also other opiates is not really recognized; even so, codeine is considered to act centrally on the cough Middle. In abnormal doses, codeine will depress respiration.
Drop off any unused narcotic medicine in a drug get-back location immediately. If you do not Use a drug consider-again area in your area, flush any unused narcotic medicine down the bathroom.
Usually do not flush down a bathroom or pour down a drain Except if you will be explained to to take action. Verify with your pharmacist For those who have questions on The easiest method to throw out medicines. There might be drug just take-again plans in your area. Consumer Info Use and Disclaimer
Sleep apnea, heritage of—Promethazine should NOT be Utilized in patients with any of such conditions .
If somebody has overdosed and has critical signs and symptoms for example passing out or difficulties respiratory, simply call 911. If not, contact a poison Manage Middle straight away.
Prescription costs may vary more info from pharmacy to pharmacy and therefore are subject matter to vary. The pricing estimates offered are determined by The newest information and facts accessible and will adjust dependant on when you actually fill your prescription on the pharmacy.